• We make platelets.

WHY USE PLATELETS
TO TREAT CANCER?

Millions of years of evolution have already prepared the perfect cell to deliver drugs to tumors and target cancer: the platelet.

“While other drug companies struggle to create new synthetic ways to deliver drugs, Mother Nature has already spent millions of years creating the perfect drug delivery system: platelets.”

JOSEPH ITALIANO, PHD
Associate Professor of Medicine, Harvard Medical School and Co-Founder, Platelet BioGenesis

Platelets naturally home to solid tumors, which have been described as “wounds that do not heal.” [Harold F. Dvorak, Tumors: Wounds That Do Not Heal. New England Journal of Medicine. 1986] Unlike most every other transplantable cell, platelets do not have a nucleus and are therefore incapable of proliferation and cannot cause cancer. Platelet circulation time in the blood is predictably short (10 days) and tunable, which makes them ideal delivery vehicles for drugs.

Most importantly, unlike red blood cells, platelets possess secretory granules, which can hide a drug payload and then deliver it upon arrival at the site of a tumor.

Platelets are Nature’s Delivery Vehicles

Mesenchymal stem cells, red blood cells and platelets can express multiple drugs on their surface, and control relative concentration of each drug.

Anucleate cells have reduced regulatory risk. Only RBCs and platelets are anucleate. Both are vascular cells that naturally circulate, touching every organ in the body.

Only PLATELETS have secretory granules that conceal drug payload until release at target. Only PLATELETS naturally home to tumors.

Purple graphic with icons for platelets, red blood cells and stem cells